Síndrome de hiperestimulación ovárica espontáneo en un embarazo con una mola invasiva: reporte de un caso / Spontaneous hyperstimulation ovarian syndrome in gestational trophoblastic disease: case report

ANTECEDENTES: El Síndrome de Hiperestimulación Ovárica (SHO) ocurre cuando los ovarios se hiperestimulan y se agrandan con la presencia de múltiples quistes foliculares y extravasación aguda de líquido desde el espacio intravascular hacias los compartimentos del tercer espacio. La presentación espontánea es infrecuente, de aparición más tardía y dentro de su patogénesis implica distinos factores, tales como genéticos y/o valores hormonales suprafisiológicos. CASO CLÍNICO: Paciente de 18 años, acude al servicio de urgencias por presentar embarazo de 14 semanas, acompañándose de dolor abdominal y sangrado transvaginal. Se mide fracción beta de la hormona Gonadotropina Coriónica humana (hCG), la cual se reporta en 3,932,600 mUI/ml. Vitalidad no se observa por ultransonido vaginal. Se procede a realizar evacuación uterina por aspiración manual endouterina y se inicia quimioprofilaxis con metotrexate / ácido folínico. Se documenta derrame pleural bilateral, derrame pericárdico. Se realiza ventana pericárdica y el derrame pleural se envía a patología y posteriormente se recaban resultados de patología con diagnóstico definitivo de embarazo molar completo / enfermedad trofoblástica metastásica. CONCLUSIÓN: Síndrome extremadamente raro de manera endógena. La evacuación del contenido intrauterino es la piedra angular del tratamiento. El inicio clínico de los síntomas masivos en las pacientes ocurre cuando la hCG empieza a declinar, iniciando edema periferico masivo, taquicardia y pulso paradójico. Lo anterior puede explicarse, en parte, por la liberación de sustancias vasoactivas en la placenta durante la evacuación. Por lo tanto, pacientes con SHO espontáneo y la posterior finalización del embarazo deben de tener un seguimiento estrecho

BACKGROUND: Ovarian hyperstimulation syndrome develops with bilateral ovarian enlargement and the present of fluid at the third space in the body compartments, the spontaneous manifestation is quite uncommon the late onset of the syndrome is related to several factors among them, pathological hormonal measurements and genetic factors. Clinical case: 18 years female with abnormal vaginal bleeding and pregnancy presenting at the emergency room, the pregnancy was diagnosticated as a miscarriage at 14 weeks and the levels of beta fraction of human chorionic hormone showed a nearly 4 million mUi/ml. no embryonic activity was observed by endovaginal ultrasound The uterine contents were aspirated and metrotexate as a chemotherapeutic drug was initiated. A pericardial effusion was drained and sent to pathological analysis. The diagnosis reported was a metastatic trophoblastic gestational disease. CONCLUSION: Extremely rare syndrome endogenously. Evacuation of intrauterine contents is the cornerstone of treatment. The clinical onset of massive symptoms in patients occurs when hCG begins to decline, initiating massive peripheral edema, tachycardia, and a paradoxical pulse. This can be explained, in part, by the release of vasoactive substances in the placenta during evacuation. Therefore, patients with spontaneous OHSS and subsequent termination of pregnancy should be closely followed

Comparing Strategies for Lipid Lowering in Argentina: An Analysis from the CVD Policy Model-Argentina.

INTRODUCTION: In Argentina, the national guidelines for lipid control emphasize the use of relatively inexpensive low- or moderate-potency statins by patients at high risk (>20 %) of a cardiovascular event. The objective of this study was to compare the impact and costs of the current national CVD prevention guidelines with regard to morbidity and mortality in Argentina with the impact and costs of three strategies that incorporate high-potency statins. METHODS: We used the CVD Policy Model-Argentina to model the proposed interventions. This model is a national-scale, state-transition (Markov) computer simulation model of the CVD incidence, prevalence, mortality, and costs in adults 35-84 years of age. We modeled three scenarios: scenario 1 lowers the risk threshold for treatment to >10 % according the Framingham Risk Score (FRS); scenario 2 intensifies statin potency under current treatment thresholds; and scenario 3 combines both scenarios by lowering the treatment threshold to ≥10 % FRS and intensifying statin potency. RESULTS: Scenario 1 would translate into 1400 fewer MIs and 500 fewer CHD deaths every year, a 3 % and 2 % reduction, respectively. Scenario 2 would lead to 2000 fewer MIs and 1000 fewer CHD deaths every year. Scenario 3 would result in the greatest reduction in MIs and CHD deaths, with 3400 fewer MIs and 1400 fewer CHD deaths every year, which translates to a 7 % and 6 % reduction, respectively. All scenarios were cost-effective if the cost of a high-potency statin pill was under US$0.25. CONCLUSION: Incorporating those individuals with greater than 10 % cardiovascular risk and the use of high-potency statins into Argentina's national lipid guidelines could result in fewer CHD deaths and events at a reasonable cost.

An empirical analysis of cigarette demand in Argentina.

OBJECTIVE: To estimate the long-term and short-term effects on cigarette demand in Argentina based on changes in cigarette price and income per person >14 years old. METHOD: Public data from the Ministry of Economics and Production were analysed based on monthly time series data between 1994 and 2010. The econometric analysis used cigarette consumption per person >14 years of age as the dependent variable and the real income per person >14 years old and the real average price of cigarettes as independent variables. Empirical analyses were done to verify the order of integration of the variables, to test for cointegration to capture the long-term effects and to capture the short-term dynamics of the variables. RESULTS: The demand for cigarettes in Argentina was affected by changes in real income and the real average price of cigarettes. The long-term income elasticity was equal to 0.43, while the own-price elasticity was equal to -0.31, indicating a 10% increase in the growth of real income led to an increase in cigarette consumption of 4.3% and a 10% increase in the price produced a fall of 3.1% in cigarette consumption. The vector error correction model estimated that the short-term income elasticity was 0.25 and the short-term own-price elasticity of cigarette demand was -0.15. A simulation exercise showed that increasing the price of cigarettes by 110% would maximise revenues and result in a potentially large decrease in total cigarette consumption. CONCLUSION: Econometric analyses of cigarette consumption and their relationship with cigarette price and income can provide valuable information for developing cigarette price policy.

Determinación de metas de factores de riesgo para enfermedades no transmisibles para 2016

INTRODUCCIÓN: Para fijar las metas en salud pública, es aconsejable utilizar un procedimiento científico riguroso que contemple el uso de toda la evidencia epidemiológica disponible. OBJETIVOS: Proyectar la evolución de los factores de riesgo para enfermedades no transmisibles y el potencial impacto de distintas intervenciones poblacionales sobre su prevalencia. MÉTODOS: Se utilizó el software STELLA® para proyectar la evolución de la prevalencia de los factores de riesgo en un escenario basal (sin intervención) y se modelaron los efectos que podrían tener distintas intervenciones para determinar su impacto. RESULTADOS: Según las estimaciones para 2016, la prevalencia de tabaquismo,hipertensión arterial, hipercolesterolemia, diabetes, obesidad e inactividad física será de 24,9%, 35,7%, 31,1%, 11,7%, 22,8% y 65,0% respectivamente, en caso de mantenerse la tendencia actual. Sin embargo, la implementación de intervenciones poblacionales podría revertir esta tendencia y reducir las prevalencias a 22,1%, 31,7%, 27,6%, 10,6%, 20,2% y 60,0% respectivamente. CONCLUSIONES: Aunque se espera un aumento en los factores de riesgo, la implementación de intervenciones poblacionales podría disminuir la carga de las enfermedades no transmisibles en Argentina.

Determinación de metas de factores de riesgo para enfermedades no transmisibles para 2016 / Assessment of Goals on Non-Communicable Disease Risk Factores for 2016

Para fijar las metas en salud pública, es aconsejable utilizar un procedimiento científico riguroso que contemple el uso de toda la evidencia epidemiológica disponible. OBJETIVOS: Proyectar la evolución de los factores de riesgo para enfermedades no transmisibles y el potencial impacto de distintas intervenciones poblacionales sobre su prevalencia. MÉTODOS:Se utilizó el software STELLA® para proyectar la evolución de la prevalencia de los factores de riesgo en un escenario basal (sin intervención)y se modelaron los efectos que podrían tener distintas intervenciones para determinar su impacto. RESULTADOS: Según las estimaciones para 2016, la prevalencia de tabaquismo, hipertensión arterial, hipercolesterolemia, diabetes, obesidad e inactividad física será de 24,9...

The setting of public health targets should use a strict scientific procedure which includes all the epidemiological evidence available. OBJECTIVES:To project the evolution of non-communicable disease risk factors and the potential impact of different population-based interventions. METHODS: TheSTELLA® software was used to project the risk factor prevalence both without interventions and with the possible effect of different interventions. RESULTS: According to the estimates for 2016, the rates of smoking, hypertension, hypercholesterolemia, diabetes, obesity and physical inactivity will be 24.9...

Determinación de metas de factores de riesgo para enfermedades no transmisibles para 2016 / Assessment of Goals on Non-Communicable Disease Risk Factores for 2016

Para fijar las metas en salud pública, es aconsejable utilizar un procedimiento científico riguroso que contemple el uso de toda la evidencia epidemiológica disponible. OBJETIVOS: Proyectar la evolución de los factores de riesgo para enfermedades no transmisibles y el potencial impacto de distintas intervenciones poblacionales sobre su prevalencia. METODOS:Se utilizó el software STELLA« para proyectar la evolución de la prevalencia de los factores de riesgo en un escenario basal (sin intervención)y se modelaron los efectos que podrían tener distintas intervenciones para determinar su impacto. RESULTADOS: Según las estimaciones para 2016, la prevalencia de tabaquismo, hipertensión arterial, hipercolesterolemia, diabetes, obesidad e inactividad física será de 24,9...(AU)

The setting of public health targets should use a strict scientific procedure which includes all the epidemiological evidence available. OBJECTIVES:To project the evolution of non-communicable disease risk factors and the potential impact of different population-based interventions. METHODS: TheSTELLA« software was used to project the risk factor prevalence both without interventions and with the possible effect of different interventions. RESULTS: According to the estimates for 2016, the rates of smoking, hypertension, hypercholesterolemia, diabetes, obesity and physical inactivity will be 24.9...(AU)

Smoking Behavior and Demographic Risk Factors in Argentina: A Population-Based Survey.

BACKGROUND: Demographic and socioeconomic factors associated with smoking behavior were evaluated in a nationwide household survey in Argentina to describe the status of the tobacco epidemic. METHODS: Face-to-face interviews with adults, age 20 and older, assessed smoking status, frequency, and age of initiation. Multivariate logistic regression was used to compare social and demographic characteristics. RESULTS: Of the 43,863 participants, 38% of men and 24% of women were current smokers, and 20% of current smokers smoked occasionally. For older men and women, smoking was less prevalent and their probability of quitting higher. Men with more than high school education were less likely to be current smokers. Rates for women did not differ by education. CONCLUSIONS: The lower smoking rates among men with more education suggest that Argentina has begun to transition to the next stage of the tobacco epidemic. Tobacco control policy must direct efforts to change smoking behavior.

Rearing management of rabbit males selected by high growth rate: the effect of diet and season on semen characteristics.

A total of sixty-six young males were used to evaluate the effect of low (L), medium (M) and high (H) concentrations of dietary digestible energy received during the rearing seasons (autumn and spring) on the performance and main semen characteristics of males for artificial insemination selected by a high growth rate. Males reared during the spring season presented a significantly higher weight at weaning than those reared during the autumn season (P < 0.001), and these differences were maintained until the end of the trial. The requirements of the males were easily covered as a general rule. In the autumn group, the males were unable to intake the digestible protein recommended only during their 3rd month of life, especially with low concentrate diets (P < 0.05). H males showed higher semen concentration and production during the autumn season, while L males showed a higher semen concentration and production than M males during the spring season, the H group showed intermediate values (P < 0.001). Males reared during the spring season showed significantly higher values of sperm concentration (P < 0.01) and production (P < 0.01). H males presented a lower percentage of spermatozoa with cytoplasmic droplets than the L group (P < 0.05) and the lowest values for sperm abnormalities during the autumn season, while the L group presented higher values for percentage abnormalities, especially during the last month controlled (P < 0.05). As a general rule, the main motility parameters controlled were not affected by the rearing diet received nor the season. These results seem to indicate that the management of rabbit males during the growing and rearing periods seem to significantly affect their subsequent performance and semen production.

The influence of intense exercise-based physical therapy program on back pain anticipated before and induced by physical activities.

BACKGROUND CONTEXT: Pain anticipated before and induced by physical activities has been shown to influence the physical performance of patients with chronic back pain. Limited data exist as to the influence of treatment on this component of pain. PURPOSE: This study attempted to determine if pain anticipated before and induced by physical activities was altered during an exercise-oriented physical therapy program for chronic back pain. STUDY DESIGN/SETTING: Subjects were recruited from three physical therapy sites with similar spine rehabilitation programs that used intense exercise delivered in a group format. During the recruitment period, 70 subjects with chronic low back pain and disability agreed to participate and complied with recommended treatments. The primary outcome measures were anticipated and induced pain as assessed by visual analog scales (VAS) during six tests of back flexibility and strength. Additional outcome measures included the performance levels of these six tests (trunk flexion, extension, straight leg raising, back strength, lifting from floor to waist and waist to shoulder height), global back and leg VAS and Oswestry Low Back Pain Disability Questionnaire scores. METHODS: At evaluation for the spine rehabilitation programs, we recorded the anticipated and induced pain levels associated with the six tests of back function, the performance levels on each test and global pain and disability scores. Subjects then participated in the spine rehabilitation program that consisted of intense exercise delivered up to three times per week, for 2 hours over a period of 6 weeks. All outcome measures were reassessed at discharge. Pre- and posttreatment outcome scores were statistically compared using paired sample t tests and chi-squared test. Spearman correlation coefficients were used to compare anticipated and induced pain results with global back and leg pain VAS scores, Oswestry scores and physical performance levels for each physical test. RESULTS: Most measures of anticipated and induced pain improved between evaluation and discharge. Improvements were noted for global back pain (p<.001), leg pain (p=.001), disability (p<.001) and performance on each physical testing (p<.001) after treatment. Performances on all physical testing correlated with anticipated and induced pain for all tests at evaluation but only for measures of flexibility at discharge. Improvements in global pain and disability correlated with improvements in anticipated and induced pain with physical testing. CONCLUSION: Anticipated and induced pain with physical activities was lessened after physical therapy using exercise. Anticipated and induced pain with physical activities related to physical performance levels, global pain and disability ratings. These findings may help explain how exercise exerts a positive influence on chronic back pain and disability.

Exercise as a treatment for chronic low back pain.

BACKGROUND CONTEXT: Exercise is a widely prescribed treatment for chronic low back pain, with demonstrated effectiveness for improving function and work. PURPOSE: The goal of this article is to review several key aspects about the safety and efficacy of exercise that may help clinicians understand its utility in treating chronic back pain. STUDY DESIGN/SETTING: A computerized literature search of MEDLINE was conducted using "exercise," "fitness," "back pain," "backache" and "rehabilitation" as search words. Identified abstracts were scanned, and useful articles were acquired for further review. Additional references were acquired through the personal collections of research papers possessed by the authors and by reviewing prior review articles on this subject. These final papers were scrutinized for data relevant to the key aspects about exercise covered in this article. RESULTS: For people with acute, subacute or chronic low back pain, there is no evidence that exercise increases the risk of additional back problems or work disability. To the contrary, current medical literature suggests that exercise has either a neutral effect or may slightly reduce risk of future back injuries. Exercise can be prescribed for patients with chronic low back pain with three distinct goals. The first and most obvious goal is to improve or eliminate impairments in back flexibility and strength, and improve performance of endurance activities. There is a large body of evidence confirming that this goal can be accomplished for a majority of patients with chronic low back pain. The second goal of exercise is to reduce the intensity of back pain. Most studies of exercise have noted overall reduction in back pain intensity that ranges from 10% to 50% after exercise treatment. The third goal of exercise is to reduce back pain-related disability through a process of desensitization of fears and concerns, altering pain attitudes and beliefs and improving affect. The mechanisms through which exercise can accomplish this goal have been the subject of substantial research. CONCLUSIONS: Exercise is safe for individuals with back pain, because it does not increase the risk of future back injuries or work absence. Substantial evidence exists supporting the use of exercise as a therapeutic tool to improve impairments in back flexibility and strength. Most studies have observed improvements in global pain ratings after exercise programs, and many have observed that exercise can lessen the behavioral, cognitive, affect and disability aspects of back pain syndromes.

Comparison of short- and long-term outcomes for aggressive spine rehabilitation delivered two versus three times per week.

BACKGROUND CONTEXT: Rehabilitation services using intensive exercise for the treatment of chronic spinal pain have traditionally been scheduled at a frequency of three times per week. PURPOSE: In an attempt to reduce the cost of rehabilitation services, this study was designed to determine whether treatment offered two times per week could produce similar outcomes when compared with an established three times per week spine therapy program. STUDY DESIGN: Prospective cohort study. PATIENT SAMPLE: Seventy-seven consecutive patients with chronic spinal pain were treated with aggressive spine rehabilitation either two or three times per week. OUTCOME MEASURES: Flexibility, trunk strength and lifting capacity were quantified before and after treatment. Pain visual analog scores and Oswestry disability scores were measured before and after treatment, as well as 12 months after treatment. METHODS: A two times per week physical therapy program was developed to be identical in its treatment method to an established three times per week, group-oriented physical therapy program used for the treatment of chronic spinal pain. Patients with spinal pain who continued to work despite chronic pain complaints were allowed to choose between the two therapy programs based on availability of treatment slots and convenience. Treatment consisted of non-pain contingent quota-based exercises targeting identified physical impairments. Treatment sessions lasted for 2 hours and consisted of 30 minutes of stretching, 30 minutes of low-impact step aerobics class and 1 hour of exercise on strength and endurance equipment. Therapy occurred in groups consisting of a maximum of eight patients who were closely supervised by two therapists. Targeted treatment time was 6 weeks. At 12 months after treatment, subjects were surveyed by mailed questionnaires. RESULTS: Seventy-seven patients with chronic spinal pain with a mean duration of symptoms of 32 months underwent treatment. Twenty-four subjects opted for the twice per week and 53 opted for the three times per week treatment. Seventy-one percent of subjects responded to the 12-month follow-up questionnaire. Physical and self-reported measures improved with both treatment frequencies. There were no differences in outcomes between treatment frequencies for measured flexibility, trunk strength, lifting capacity, pain intensity scores or Oswestry scores at the completion of treatment. At 12-month follow-up, no differences were noted between treatment frequencies for pain scores, Oswestry scores, patients' perceptions of adequacy of treatment, posttreatment exercise compliance or use of other treatments for their spinal problem. Total therapy visits were less in the two than three times per week groups (12 vs 15 visits). CONCLUSION: Similar outcomes were obtained from aggressive spine rehabilitation occurring two versus three times per week in patients presenting with moderate levels of chronic spinal pain. Reduction in physical therapy services and therefore cost did not adversely affect clinical outcomes in the treatment of this patient population.